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Active substance: mercaptopurine (mercaptopurine). Pharmachologic effect: Purinethol has antitumor and immunosuppressive effects. It is a very competitive antagonist of purine bases. Indications for use: acute lymphoblastic leukemia; acute myeloid leukemia; persistent myeloid leukemia (induction of remission and maintenance therapy). Purinethol can be utilized both as monotherapy and in conjunction with other cytostatic in various doses, based on the therapy plan. Normally for children and adults, the dose is 50-75 mg / m2 or 2.5 mg / kg / day; Later, everyday Purinethol dosage is modified based on the effect. At first warning signs of serious leukopenia, it is recommended interrupt the ingestion for 2-3 days. If leukopenia does not aggravate during this time period of time, the therapy is resumed. In aged sufferers, it is recommended to monitor hardworking liver and renal system function. If signs of kidney or hepatic malfunction are discovered, the dosage should be lowered. The the dose also need to be lowered for individuals with hepatic and / or renal deficiency.When combined with allopurinol, the dose of Mercaptopurine is reduced to 25% of the normal dose, since allopurinol reduces the metabolic rate of Mercaptopurine. Buy Purinethol without prescription on the internet at the greatest price. Negative effects. From the side of hematopoiesis: generally - leukopenia, thrombocytopenia, anemia. Reactions from the defense mechanisms: allergy or intolerance reactions: rarely - arthralgia, skin break outs, drug fever; seldom - swelling. On the gastrointestinal system part: often - nausea, sickness, anorexia, intrahepatic cholestasis, hepatotoxicity (hepatotoxicity has a toxic-allergic genesis and happens when the advised dose of 2.5 mg / kg / day or 75 mg / m2 / day is exceeded; hardly ever - ulceration of the oral mucosa, diarrhea, pancreatitis, hepatonecrosis; almost never - ulceration of the intestinal mucosa. Other: dropped defense, accession of secondary infections, skin hyperpigmentation; hyperuricemia and nephropathy due to tumor lysis; very rarely - the introduction of secondary leukemia, myelodysplasia and hepatolienal T-cell lymphoma. Click on the website link for More information on Purinethol France and greatest spot to get for more info
Contraindications for use are the pursuing: pregnant state; lactation period, allergic reaction to Mercaptopurine or other parts of the drug. Overdose signs or symptoms: instant - queasiness, nausea or vomiting, anorexia, diarrhea; delayed - myelosuppression, hardworking liver disorder, gastroenteritis. Special directions! Purinethol must be used only under doctor’s guidance and the physician must have experience in the usage of cytostatics. Therapy should be executed under professional medical supervision. Do not wait to follow the url for more information about Mercaptopurine France and finest internet site to buy Purinethol Without Prescription for reasonable.